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Topoisomerase II inhibitor 13

CAS No. 451515-89-2

Topoisomerase II inhibitor 13( —— )

Catalog No. M36061 CAS No. 451515-89-2

Topoisomerase II inhibitor 13 inhibits topoisomerase II (Topo II) that shows strong anti-proliferation activity against HL-60/MX2 cancer cells derived from HL-60 against Topo II toxicity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 121 In Stock
50MG 180 In Stock
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Biological Information

  • Product Name
    Topoisomerase II inhibitor 13
  • Note
    Research use only, not for human use.
  • Brief Description
    Topoisomerase II inhibitor 13 inhibits topoisomerase II (Topo II) that shows strong anti-proliferation activity against HL-60/MX2 cancer cells derived from HL-60 against Topo II toxicity.
  • Description
    Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    Topoisomerase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    451515-89-2
  • Formula Weight
    413.48
  • Molecular Formula
    C22H23N9
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 12.5 mg/mL (30.23 mM )
  • SMILES
    NC1=C(C=2C(N1CCCN(CC)CC)=NC(C#N)=C(C#N)N2)C=3NC=4C(N3)=CC=CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li P H, et al. Synthesis and mechanism studies of 1, 3-benzoazolyl substituted pyrrolo [2, 3-b] pyrazine derivatives as nonintercalative topoisomerase II catalytic inhibitors. Journal of Medicinal Chemistry, 2016, 59(1): 238-252.
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